Yoshida Y, Fukuda T, Tanihara T, Nishikawa N, Iwasa S, Adachi S, Zaitsu O, Terada Y, Tsukamoto R, Shimoshikiryo H, Fukuoka K, Tsurusaki F, Hamamura K, Oyama K, Tsuruta A, Koyanagi S, Matsunaga N, Ohdo S.
Circadian rhythms in CYP2A5 expression underlie the time-dependent effect of tegafur on breast cancer.
Biochem Biophys Res Commun. [Epub ahead of print], 2024 May 14
Sato A, Yasukochi S, Iwanaka N, Yamauchi T, Tsuruta A, Koyanagi S, Ohdo S.
Dosing time-dependent difference in the suppressive effect of empagliflozin on the development of mechanical pain hypersensitivity in diabeteic mice
J Pharmacol Exp Ther. [Epub ahead of print], 2024 Mar 8
Yoshida Y, Fukuoka K, Sakugawa M, Kurogi M, Hamamura K, Hamasaki K, Tsurusaki F, Sotono K, Nishi T, Fukuda T, Kumamoto T, Oyama K, Ogino T, Tsuruta A, Mayanagi K, Yamashita T, Fuchino H, Kawahara N, Yoshimatsu K, Kawakami H, Koyanagi S, Matsunaga N, Ohdo S.
Inhibition of G protein-coupled receptor 68 using homoharringtonine attenuates chronic kidney disease-associated cardiac impairment.
Transl Res. [Epub ahead of print], 2024 Feb 23
Tsurudome Y, Yoshida Y, Hamamura K, Ogino T, Yasukochi S, Yasuo S, Iwamoto A, Yoshihara T, Inazumi T, Tsuchiya S, Takeo T, Nakagata N, Higuchi S, Sugimoto Y, Tsuruta A, Koyanagi S, Matsunaga N, Ohdo S.
Prostaglandin F2α Affects the Cycle of Clock Gene Expression and Mouse Behavior.
Int J Mol Sci. [Epub ahead of print], 2024 Feb 2
Yamakawa W, Yasukochi S, Tsurudome Y, Kusunose N, Yamaguchi Y, Tsuruta A, Matsunaga N, Ushijima K, Koyanagi S, Ohdo S.
Suppression of nueropathic pain in the circadian clock-dificient Per2m/m mice involves up-regulation of endocannabinoid system
PNAS nexus. [Epub ahead of print], 2024 Jan 17
Yoshida Y, Fukuda T, Fukuoka K, Nagayama T, Tanihara T, Nishikawa N, Otsuki K, Terada Y, Hamamura K, Oyama K, Tsuruta A, Mayanagi K, Koyanagi S, Matsunaga N, Ohdo S.
Time-Dependent Differences in Vancomycin Sensitivity of Macrophages Underlie Vancomycin-Induced Acute Kidney Injury.
J Pharmacol Exp Ther. [Epub ahead of print], 2024 Jan 2
Tsuruta A, Kanetani D, Shiiba Y, Inoki T, Yoshida Y, Matsunaga N, Koyanagi S, Ohdo S.
Modulation of cell physiology by bispecific nanobodies enabling changes in the intracellular localization of organelle proteins
Biochem Pharmacol. [Epub ahead of print], 2023 Jul 26
Fukuoka K, Yoshida Y, Sotono K, Nishikawa N, Hamamura K, Oyama K, Tsuruta A, Mayanagi K, Koyanagi S, Matsunaga N, Ohdo S.
Oral administration of vancomycin alleviates heart failure triggered by chronic kidney disease
Biochem Biophys Res Commun. [Epub ahead of print], 2023 Jul 10
Taniguchi M, Yasukochi S, Yamakawa W, Tsurudome Y, Tsuruta A, Horiguchi M, Ushijima K, Yamashita T, Shindo N, Ojida A, Matsunaga N, Koyanagi S, Ohdo S.
Inhibition of tumor-derived CCL2 expression attenuates tactile allodynia in NCTC 2472 fibrosarcoma-inoculated mice
Mol Pharmacol. [Epub ahead of print], 2023 Jun 9
Jaballah N, Tsurudome Y, Murakami C, Matsunaga N, Ushijima K, Koyanagi S, Ohdo S.
The scaffold protein PDZK1 governs diurnal localization of CNT2 on the plasma membrane in mouse intestinal epithelial cells
J Biochem. [Epub ahead of print], 2023 May 9
Uchinomiya S, Nagaura T, Weber M, Matsuo Y, Zenmyo N, Yoshida Y, Tsuruta A, Koyanagi S, Ohdo S, Matsunaga N, Ojida A
Fluorescence-Based Detection of Fatty Acid β-Oxidation in Cells and Tissues Using Quinone Methide-Releasing Probes
J Am Chem Soc. [Epub ahead of print], 2023 Apr 3
Hashikawa KI, Tsuruta A, Yamakawa W, Yasukochi S, Koyanagi S, Ohdo S
Senescence-induced alteration of circadian phagocytic activity of retinal pigment epithelium cell line ARPE-19
Biochem Biophys Res Commun. [Epub ahead of print], 2023 Mar 30
Mine K, Kawasiri T, Inoue M, kobayashi D, Mori K, Hiromoto S, Kudamatsu H, Ucida M, Egashira N, Koyanagi S, Ohdo S, Shimazoe T.
Omeprazole Suppresses Oxaliplatin-Induced Peripheral Neuropathy in a Rodent Model and Clinical Database
Int J Mol Sci. [Epub ahead of print], 2022 Aug 9
Ohdo S, Koyanagi S, Matsunaga N
Chronopharmacology of immune-related diseases
Allergol Int. [Epub ahead of print], 2022 Jul 15
Omata Y, Okawa M, Haraguchi M, Tsuruta A, Matsunaga N, Koyanagi S, Ohdo S.
RNA editing enzyme ADAR1 controls miR-381-3p-mediated expression of multidrug resistance protein MRP4 via regulation of circRNA in human renal cells
J Biol Chem. [Epub ahead of print], 2022 Jun 23
Koyanagi S, Kusunose N, Yasukochi S, Ohdo S.
Basis for diurnal exacerbation of neuropathic pain hypersensitivity and its application for drug development
J Biochem. [Epub ahead of print], 2022 May 11
Tsuruta A, Shiiba Y, Matsunaga N, Fujimoto M, Yoshida Y, Koyanagi S, Ohdo S
Diurnal expression of PD-1 on tumor-associated macrophages underlies the dosing time-dependent anti-tumor effects of the PD-1/PD-L1 inhibitor BMS-1 in B16/BL6 melanoma-bearing mice.
Mol Cancer Res. [Epub ahead of print], 2022 Feb 21
Yoshida Y, Matsunaga N, Nakao T, Hamamura K, Kondo H, Ide T, Tsutsui H, Tsuruta A, Kurogi M, Nakaya M, Kurose H, Koyanagi S, Ohdo S.
Alteration of circadian machinery in monocytes underlies chronic kidney disease-associated cardiac inflammation and fibrosis.
Nat Commun. [Epub ahead of print], 2021 May 13
Ogino T, Matsunaga N, Tanaka T, Tanihara T, Terajima H, Yoshitane H, Fukada Y, Tsuruta A, Koyanagi S, Ohdo S.
Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells.
Elife. [Epub ahead of print], 2021 Apr 23
Omata Y, Yamauchi T, Tsuruta A, Matsunaga N, Koyanagi S, Ohdo S.
RNA editing enzyme ADAR1 governs the circadian expression of P-glycoprotein in human renal cells by regulating alternative splicing of the ABCB1 gene.
J Biol Chem. [Epub ahead of print], 2021 Mar 26
Yasukochi S, Kusunose K, Matsunaga N, Koyanagi S, Ohdo S.
Sulfasalazine alleviates neuropathic pain hypersensitivity in mice through inhibition of SGK-1 in the spinal cord.
Biochemical Pharmacology. [Epub ahead of print], 2021 Jan 8
Tokunaga K, Sato M, Kuwata K, Miura C, Fuchida H, Matsunaga N, Koyanagi S, Ohdo S, Shindo N, Ojida A.
Bicyclobutane Carboxylic Amide as a Cysteine-Directed Strained Electrophile for Selective Targeting of Proteins.
J Am Chem Soc. [Epub ahead of print], 2020 Oct 13
Kato M, Tsurudome Y, Kanemitsu T, Yasukochi S, Kanado Y, Ogino T, Matsunaga N, Koyanagi S, Ohdo S.
Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time dependent changes in the oxaliplatin-induced myelotoxicity.
Sci Rep. [Epub ahead of print], 2020 Aug 10
Sato M, Fuchida H, Shindo N, Kuwata K, Tokunaga K, Xiao-Lin G, Inamori R, Hosokawa K, Watari K, Shibata T, Matsunaga N, Koyanagi S, Ohdo S, Ono M, Ojida A.
Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines.
ACS Med Chem Lett. [Epub ahead of print], 2020 Jun 11
Kusunose N, Tsuruta A, Kengo Hamamura, Tsurudome Y, Yoshida Y, Akamine T, Matsunaga N, Koyanagi S, Ohdo S.
Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular clock in mouse Peyer's patches.
Genes Cells. [Epub ahead of print], 2020 Feb 12
Uchinomiya S, Matsunaga N, Kamoda K, Kawagoe R, Tsuruta A, Ohdo S, Ojida A.
Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells.
Chem Commun (Camb). [Epub ahead of print], 2020 Feb 5
Shiromizu S, Yamauchi T, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
Dosing Time-Dependent Changes in the Anti-tumor Effect of xCT Inhibitor Erastin in Human Breast Cancer Xenograft Mice.
Biol Pharm Bull. [Epub ahead of print], 2019 Nov 1
Kanado Y, Tsurudome Y, Omata Y, Yasukochi S, Kusunose N, Akamine T, Matsunaga N, Koyanagi S, Ohdo S.
Estradiol regulation of P-glycoprotein expression in mouse kidney and human tubular epithelial cells, implication for renal clearance of drugs.
Biochem Biophys Res Commun. [Epub ahead of print], 2019 Sep 17
Nishiyama K, Numaga-Tomita T, Fujimoto Y, Tanaka T, Toyama C, Nishimura A, Yamashita T, Matsunaga N, Koyanagi S, Azuma YT, Ibuki Y, Uchida K, Ohdo S, Nishida M.
Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3-Nox2 protein complex.
Br J Pharmacol. [Epub ahead of print], 2019 Jun 26
Ohdo S, Koyanagi S, Matsunaga N.
Chronopharmacological strategies focused on chrono-drug discovery.
Pharmacol Ther. [Epub ahead of print], 2019 Jun 4
Matsunaga N, Yoshida Y, Kitajou N, Shiraishi A, Kusunose N, Koyanagi S, Ohdo S.
Microcurrent stimulation activates the circadian machinery in mice.
Biochem Biophys Res Commun. [Epub ahead of print], 2019 Feb 26
Shindo N, Fuchida H, Sato M, Watari K, Shibata T, Kuwata K, Miura C, Okamoto K, Hatsuyama Y, Tokunaga K, Sakamoto S, Morimoto S, Abe Y, Shiroishi M, Caaveiro JMM, Ueda T, Tamura T, Matsunaga N, Nakao T, Koyanagi S, Ohdo S, Yamaguchi Y, Hamachi I, Ono M, Ojida A.
Selective and reversible modification of kinase cysteines with chlorofluoroacetamides.
Nat Chem Biol. [Epub ahead of print], 2019 Jan 14
Katamune C, Koyanagi S, Hashikawa K, Kusunose N, Akamine T, Matsunaga N, Ohdo S.
Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene.
J Biol Chem. [Epub ahead of print], 2018 Nov 14
Kusunose N, Akamine T, Kobayashi Y, Yoshida S, Kimoto K, Yasukochi S, Matsunaga N, Koyanagi S, Ohdo S, Kubota T.
Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation of HIF1α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (Müller) cells.
Jpn J Ophthalmol. [Epub ahead of print], 2018 Sep 24
Kimura H, Matsunaga N, Kakimoto K, Watanabe M, Tsuruta A, Kusunose N, Shiromizu S, Koyanagi S, Ohdo S.
Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system.
Biochem Biophys Res Commun. [Epub ahead of print], 2018 Jun 30
Tsurudome Y, Koyanagi S, Kanemitsu T, Katamune C, Oda M, Kanado Y, Kato M, Morita A, Tahara Y, Matsunaga N, Shibata S, Ohdo S.
Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function.
Sci Rep. [Epub ahead of print], 2018 Jun 13
Akamine T, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
Accumulation of sorbitol in the sciatic nerve modulates circadian properties of diabetes-induced neuropathic pain hypersensitivity in a diabetic mouse model.
Biochem Biophys Res Commun. [Epub ahead of print], 2018 May 9
Matsunaga N, Ogino T, Hara Y, Tanaka T, Koyanagi S, Ohdo S.
Optimized dosing schedule based on circadian dynamics of mouse breast cancer stem cells improves the anti-tumor effects of aldehyde dehydrogenase.
Cancer Res. [Epub ahead of print], 2018
Shiromizu S, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice.
J Pharmacol Sci. 2018 Mar12
Matsunaga T, Matsunaga N, Kusunose N, Ikeda E, Okazaki H, Kakimoto K, Hamamura K, Koyanagi S, Ohdo S.
Angiotensin-II regulates dosing time-dependent intratumoral accumulation of macromolecular drug formulations via 24-h blood pressure rhythm in tumor-bearing mice.
Biochem Biophys Res Commun. 2018 Feb 19
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Kanemitsu T, Tsurudome Y, Kusunose N, Oda M, Matsunaga N, Koyanagi S, Ohdo S.
Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARα.
J Biol Chem. [Epub ahead of print], 2017
Okazaki F, Matunaga N, Hamamura K, Suzuki K, Nakao T, Okazaki H, Kutsukake M, Fukumori S, Tsuji Y, To H.
Administering xCT inhibitors based on circadian clock improves antitumor effects.
Cancer Res. [Epub ahead of print], 2017
Hashikawa K, Katamune C, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
Dysfunction of the circadian transcriptional factor CLOCK in mice resists chemical carcinogen-induced tumorigenesis.
Sci Rep. 7(1):9995, 2017
Dilixiati A, Koyanagi S, Kusunose N, Matunaga N, Ohdo S.
Dietary supplementation with essence of chicken enhances daily oscillations in plasma glucocorticoid levels and behavioral adaptation to the phase-shifted environmental light-dark cycle in mice.
J Pharmacol Sci. 134(4):211-217, 2017
Sakamoto Y, Yano T, Hanada Y, Takeshita A, Inagaki F, Matsunaga N, Koyanagi S, Ohdo S.
Vancomycin induces reactive oxygen species-dependent apoptosis via mitochondrial cardiolipin peroxidation in renal tubular epithelial cells.
Eur J Pharmacol. 800:48-56, 2017
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Tomohiro Shibata, Kosuke Watari, Hiroto Izumi, Akihiko Kawahara, Satoshi Hattori, Chihiro Fukumitsu, Yuichi Murakami, Ryuji Takahashi, Uhi Toh, Ken-ichi Ito, Shigehiro Ohdo, Maki Tanaka, Masayoshi Kage, Michihiko Kuwano and Mayumi Ono
Breast Cancer Resistance to Antiestrogens Is Enhanced by Increased ER Degradation and ERBB2 Expression
Cancer Res. 77(2):545-556, 2016.
Mahitab Elsayed, Daisuke Kobayashi, Toshio Kubota, Naoya Matsunaga, Ryusei Murata, Yuko Yoshizawa, Natsuki Watanabe, Tohru Matsuura, Yuya Tsurudome, Takashi Ogino, Shigehiro Ohdo, Takao Shimazoe
Synergistic Antiproliferative Effects of Zoledronic Acid and Fluvastatin on Human Pancreatic Cancer Cell Lines: An in Vitro Study
Biol Pharm Bull. 39(8):1238-46, 2016.
Yuki Nakamura, Nobuhiro Nakano, Kayoko Ishimaru, Noriko Ando, Ryohei Katoh, Katsue Suzuki-Inoue, Satoru Koyanagki, Hideoki Ogawa, Ko Okumura, Shigenobu Shibata, Atsuhito Nakao
Inhibition of IgE-mediated allergic reactions by pharmacologically targeting the circadian clock
J Allergy Clin Immunol. 137(4):1226-1235, 2016.
Koyanagi S, Kusunose N, Taniguchi M, Akamine T, Kanado Y, Ozono Y, Masuda T, Kohro Y, Matsunaga N, Tsuda M, Salter MW, Inoue K, ohdo S.
Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia.
Nat Commun. 7:13102, 2016.
Matsunaga N, Ikeda E, Kakimoto K, Watanabe M, Shindo N, Tsuruta A, Ikeyama H, Hamamura K, Higashi K, Yamashita T, Kondo H, Yoshida Y, Matsuda M, Ogino T, Tokushige K, Itcho K, Furuichi Y, Nakao T, Yasuda K, Doi A, Amamoto T, Aramaki H, Tsuda M, Inoue K, Ojida A, Koyanagi S, Ohdo S.
Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease.
EBioMedicine. pii: S2352-3964(16)30463-7, 2016. [Epub ahead of print]
Katamune C, Koyanagi S, Shiromizu S, Matsunaga N, Shimba S, Shibata S, Ohdo S.
Different roles of negative and positive components of the circadian clock in oncogene-induced neoplastic transformation.
J Biol Chem. 291:10541-10550, 2016.
Okazaki F, Matsunaga N, Okazaki H, Azuma H, Hamamura K, Hara Y, Tsuruta A, Tsurudome Y, Ogino T, Suzuki T, Hyodo K, Ishihara H, Kikuchi H, To H, Aramaki H, Koyanagi S, Ohdo S.
Circadian clock in a mouse colon tumor regulates intracellular iron levels to promote tumor progression.
J Biol Chem. 291:7017-7028, 2016.
Hamamura K, Matsunaga N, Ikeda E, Kondo H, Ikeyama H, Tokushige K, Itcho K, Furuichi Y, Yoshida Y, Matsuda M, Yasuda K, Doi A, Yokota Y, Amamoto T, Aramaki H, Irino Y, Koyanagi S, Ohdo S.
Alterations of hepatic metabolism in chronic kidney disease via D-box binding protein aggravate the renal dysfunction.
J Biol Chem. 291:4913-4927, 2016.
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Kusunose N, Matsunaga N, Kimoto K, Akamine T, Hamamura K, Koyanagi S, Ohdo S, Kubota T.
Mitomycin C modulates the circadian oscillation of clock gene Period 2 expression through attenuating the glucocorticoid signaling in mouse fibroblasts.
Biochem Biophys Res Commun. S0006-291: 30603-3, 2015.
Akamine T, Koyanagi S, Kusunose N, Hashimoto H, Taniguchi M, Matsunaga N, Ohdo S.
Dosing time-dependent changes in the analgesic effect of pregabalin on diabetic neuropathy in mice.
J Pharmacol Exp Ther. 354: 65-72, 2015.
Iwasaki M, Koyanagi S, Suzuki N, Katamune C, Matsunaga N, Watanabe N, Takahashi M, Izumi T, Ohdo S.
Circadian modulation in the intestinal absorption of P-glycoprotein substrates in monkeys.
Mol Pharmacol. 87: 314-322, 2015.
Wada E, Koyanagi S, Kusunose N, Akamine T, Masui H, Hashimoto H, Matsunaga N, Ohdo S.
Modulation of peroxisome proliferator-activated receptor-α activity by bile acids causes circadian changes in the intestinal expression of Octn1/Slc22a4 in mice.
Mol Pharmacol. 88: 29-37, 2015.
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Okamura A, Koyanagi S, Dilxiat A, Kusunose N, Chen JJ, Matsunaga N, Shibata S, Ohdo S.
Bile acid-regulated peroxisome proliferator-activated receptor-α (PPARα) activity underlies circadian expression of intestinal peptide absorption transporter PepT1/Slc15a1.
J Biol Chem. 289: 25296-25305, 2014.
Oda M, Koyanagi S, Tsurudome Y, Kanemitsu T, Matsunaga N, Ohdo S.
Renal circadian clock regulates the dosing-time dependency of Cisplatin-induced nephrotoxicity in mice.
Mol Pharmacol. 85: 715-722, 2014.
Matsunaga N, Itcho K, Hamamura K, Ikeda E, Ikeyama H, Furuichi Y, Watanabe M, Koyanagi S, Ohdo S.
24-Hour Rhythm of Aquaporin-3 Function in the Epidermis Is Regulated by Molecular Clocks.
J Invest Dermatol. [Epub ahead of print], 2014.
Okazaki H, Matsunaga N, Fujioka T, Okazaki F, Akagawa Y, Tsurudome Y, Ono M, Kuwano M, Koyanagi S, Ohdo S.
Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma.
Cancer Res. 74: 543-551, 2014.
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Matsunaga N, Okazaki F, Koyanagi S, Ohdo S.
Chrono-drug delivery system based on the circadian rhythm of transferrin receptor.
Nihon Rinsho. 71: 2200-2205, 2013.
Hayashi Y, Koyanagi S, Kusunose N, Okada R, Wu Z, Tozaki Saitoh H, Ukai K, Kohsaka S, Inoue K, Ohdo S, Nakanishi H.
The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S.
Sci Rep. 3: 2744-2751, 2013.
Karakawa S, Miyoshi Y, Konnno R, Koyanagi S, Mita M, Ohdo S, Hamase K.
Two-dimensional high-performance liquid chromatgraphic determination of day-night variation of D-alanine in mammals and factors controlling the
circadian changes.
Anal Bioanal Chem. 405: 8083-8091, 2013.
Ogi S, Fujita H, Kashihara M, Yamamoto C, Sonoda K, Okamoto I, Nakagawa K, Ohdo S, Tanaka Y, Kuwano M, Ono M.
Sorting nexin 2-mediated membrane trafficking of c-Met contributes to sensitivity of molecular-targeted drugs.
Cancer Sci. 104: 573-583, 2013.
Tomishima Y, Ishitsuka Y, Matsunaga N, Nagatome M, Furusho H, Irikura M, Ohdo S, Irie T.
Ozagrel hydrochloride, a selective thromboxane A?Esynthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice.
BMC Gastroenterol. 13: 21-30, 2013.
Horiguchi M, Koyanagi S, Hamdan AM, Kakimoto K, Matsunaga N, Yamashita C, Ohdo S.
Rhythmic Control of the ARF-MDM2 Pathway by ATF4 Underlies Circadian Accumulation of p53 in Malignant Cells.
Cancer Res. 73: 2639-2649, 2013.
Ikeda E, Matsunaga N, Kakimoto K, Hamamura K, Hayashi A, Koyanagi S, Ohdo S.
Molecular Mechanism Regulating 24-Hour Rhythm of Dopamine D3 Receptor Expression in Mouse Ventral Striatum.
Mol Pharmacol. 83: 959-967, 2013
Hayashi A, Matsunaga N, Okazaki H, Kakimoto K, Kimura Y, Azuma H, Ikeda E, Shiba T, Yamato M, Yamada KI, Koyanagi S, Ohdo S.
A Disruption Mechanism of the Molecular Clock in a MPTP Mouse Model of Parkinson's Disease.
Neuromolecular Med. 15: 238-251, 2013
Oishi K, Koyanagi S, Ohkura N.
The molecular clock regulates circadian transcription of tissue factor gene.
Biochem Biophys Res Commun. 431: 332-335, 2013
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Noda M, Yamakawa Y, Matsunaga N, Naoe S, Jodoi T, Yamafuji M, Akimoto N, Teramoto N, Fujita K, Ohdo S, Iguchi H.
IL-6 Receptor Is a Possible Target against Growth of Metastasized Lung Tumor Cells in the Brain.
Int J Mol Sci. 14: 515-526, 2012.
Kuroki K, Hirose K, Okabe Y, Fukunaga Y, Takahashi A, Shiroishi M, Kajikawa M, Tabata S, Nakamura S, Takai T, Koyanagi S, Ohdo S, Maenaka K.
The long-term immunosuppressive effects of disulfide-linked HLA-G dimer in mice with collagen-induced arthritis.
Hum Immunol. [Epub ahead of print], 2012.
Nakaya M, Chikura S, Watari K, Mizuno N, Mochinaga K, Mangmool S, Koyanagi S, Ohdo S, Sato Y, Ide T, Nishida M, Kurose H.
Induction of cardiac fibrosis by β-blocker in G protein-independent and G protein-coupled receptor kinase 5/β-arrestin2-dependent Signaling pathways.
J Biol Chem. 287: 35669-35677, 2012.
Ushijima K, Koyanagi S, Sato Y, Ogata T, Matsunaga N, Fujimura A, Ohdo S.
Role of activating transcription factor-4 in 24-hour rhythm of serotonin transporter expression in the mouse midbrain.
Mol Pharmacol. 82: 264-270, 2012.
Hamdan AM, Koyanagi S, Wada E, Kusunose N, Murakami Y, Matsunaga N, Ohdo S.
Intestinal expression of mouse Abcg2/Bcrp gene is under the control of circadian clock-activating transcription factor-4 pathway.
J Biol Chem. 287: 17224-17231, 2012.
Matsunaga N, Inoue M, Kusunose N, Kakimoto K, Hamamura K, Hanada Y, Toi A, Yoshimura Y, Sato F, Fujimoto K, Koyanagi S, Ohdo S.
Time-dependent Interaction Between DEC2 and C/EBPα Underlies the Circadian Expression of CYP2D6 in Serum-shocked HepG2 Cells.
Mol Pharmacol. 81: 739-747, 2012.
Horiguchi M, Koyanagi S, Okamoto A, Suzuki SO, Matsunaga N, Ohdo S.
Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors.
Cancer Res. 72: 395-401, 2012.
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Tanimura N, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
Aryl hydrocarbon receptor-mediated Cyp1a1 expression is modulated in a CLOCK-dependent circadian manner.
Toxicology.204-8, 2011.
Oishi K, Koyanagi S, Ohkura N.
Circadian mRNA expression of coagulation and fibrinolytic factors is organ-dependently disrupted in aged mice.
Exp Gerontol.46: 994-9, 2011.
Koyanagi S, Hamdan AM, Horiguchi M, Kusunose N, Okamoto A, Matsunaga N, OhdoS.
cAMP-response Element (CRE)-mediated Transcription by Activating Transcription Factor-4 (ATF4) Is Essential for Circadian Expression of the Period2 Gene.
J Biol Chem.286: 32416-23, 2011.
Ohdo S, Koyanagi S, Matsunaga N, Hamdan A.
Molecular basis of chronopharmaceutics.
J Pharm Sci.100: 3560-76, 2011.
To H, Yoshimatsu H, Tomonari M, Ida H, Tsurumoto T, Tsuji Y, Sonemoto E, Shimasaki N, Koyanagi S, Sasaki H, Ieiri I, Higuchi S, Kawakami A, Ueki Y, Eguchi K.
Methotrexate chronotherapy is effective against rheumatoid arthritis.
Chronobiol Int.28: 3560-76, 2011.
Ohdo S, Koyanagi S, Matsunaga N.
Chronopharmacology.
Nihon Yakurigaku Zasshi.137: 115-9, 2011. Review.
Tsuda M, Kohro Y, Yano T, Tsujikawa T, Kitano J, Tozaki-Saitoh H, Koyanagi S, Ohdo S, Ji RR, Salter MW, Inoue K.
JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats.
Brain.134: 1127-39, 2011.
Matsunaga N, Kohno Y, Kakimoto K, Hayashi A, Koyanagi S, Ohdo S.
Influence of CLOCK on cytotoxicity induced by diethylnitrosamine in mouse primary hepatocytes.
Toxicology.280: 144-51, 2011.
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Kusunose N, Koyanagi S, Hamamura K, Matsunaga N, Yoshida M, Uchida T, Tsuda M, Inoue K, Ohdo S.
Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain.
Mol. Pain. 6: 83, 2010.
Hayashida S, Kuramoto Y, Koyanagi S, Oishi K, Fujiki J, Matsunaga N, Ikeda E, Ohdo S, Shimeno H, Soeda S.
Proxisome proliferator-activated receptor-alpha mediates high-fat, diet-enhanced daily oscillation of plasminogen activator inhibitor-1 activity in mice.
Chronobiol. Int. 27: 1735-1753, 2010.
Fujioka T, Matsunaga N, Okazaki H, Koyanagi S, Ohdo S.
Hypoxia-response plasmid vector producing bcl-2 shRNA enhances the apoptotic cell death of mouse rectum carcinoma.
J. Pharmacol. Sci. 113: 353-361, 2010.
Ohdo S, Koyanagi S, Matsunaga N.
Chronopharmacological strategies: Intra- and inter-individual variability of molecular clock.
Adv. Drug Deliv. Rev. 62: 885-897, 2010.
Okazaki F, Matsunaga, N, Okazaki H, Utoguchi N, Suzuki R, Maruyama K, Koyanagi S, Ohdo, S.
Circadian rhythm of transferrin receptor 1 gene expression controlled by c-Myc in colon cancer-bearing mice.
Cancer Res. 70: 6238-6246, 2010.
Ohdo S.
Chrono-drug-delivery focused on biological clock: intra- and inter-individual variability of molecular clock.
Adv. Drug Deliv. Rev. 62: 857-858, 2010.
Oishi K, Koyanagi S, Matsunaga N, Kadota K, Ikeda E, Hayashida S, Kuramoto Y, Shimeno H, Soeda S, Ohdo S.
Bezafibrate induces plasminogen activator inhibitor-1 gene expression in a CLOCK-dependent circadian manner.
Mol. Pharmacol. 78: 135-141, 2010.
Burioka N, Fukuoka Y, Koyanagi S, Miyata M, Takata M, Chikumi H, Takane H, Watanabe M, Endo M, Sako T, Suyama H, Ohdo S, Shimizu E.
Asthma: Chronopharmacotherapy and the molecular clock.
Adv. Drug Deliv. Rev. 62: 946-955, 2010.
Horiguchi M, Kim J, Matsunaga N, Kaji H, Egawa T, Makino K,Koyanagi S, Ohdo, S.
Glucocorticoid-dependent expression of O(6)-methylguanine-DNA methyltransferase gene modulates dacarbazine-induced hepatotoxicity in mice.
J. Pharmacol. Exp. Ther. 333: 782-787, 2010.
Ohdo S.
Chronotherapeutic strategy: Rhythm monitoring, manipulation and disruption.
Adv. Drug Deliv. Rev. 62: 859-875, 2010.
Ohdo S.
Chronopharmaceutics: pharmaceutics focused on biological rhythm.
Biol Pharm Bull. 33: 159-167, 2010.
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Akagi T, Fukagawa T, Kage Y, To H, Matsunaga M, Koyanagi S, Uchida A, Fujii1 A, Iba H, Ikemura T, Aramaki H, Higuchi S, Ohdo S.
Role of glucocorticoid receptor in the regulation of cellular sensitivity to irinotecan hydrochloride.
J. Pharmacol. Sci. 109:265-74, 2009.
Tojo Y, Hamase K, Konno R, Koyanagi S, Ohdo S, Zaitsu K.
Simple and rapid genotyping of D-amino acid oxidase gene recognizing a crucial variant in the ddY strain using microchip electrophoresis.
J Sep Sci. 32:430-436, 2009.
Kim J, Matsunaga N, Koyanagi S, Ohdo S.
Clock gene mutation modulates the cellular sensitivity to genotoxic stress through altering the expression of N-methylpurine DNA glycosylase gene.
Biochem Pharmacol.78(8),1075-1082,2009.
Burioka N, Koyanagi S, Fukuoka Y, Okazaki F, Fujioka T, Kusunose N, Endo M, Suyama H, Chikumi H, Ohdo S, Shimizu E.
Influence of intermittent hypoxia on the signal transduction pathways to inflammatory response and circadian clock regulation.
Life Sci.85(9-10),372-378,2009.
Sonoki K, Iwase M, Sasaki N, Ohdo S, Higuchi S, Matsuyama N, Iida M.
Relations of lysophosphatidylcholine in low-density lipoprotein with serum lipoprotein-associated phospholipase A2, paraoxonase and homocysteine thiolactonase activities in patients with type 2 diabetes mellitus.
Diabetes Res Clin Pract.86(2),117-123. 2009.
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Murakami Y, Higashi Y, Matsunaga N, Koyanagi S, Ohdo S.
Circadian clock-controlled intestinal expression of the multidrug-resistance gene mdr1a in mice.
Gastroenterology 135: 1636-1644, 2008.
Matsunaga N, Ikeda M, Takiguchi T, Koyanagi S, and Ohdo S.
The molecular mechanism regulating 24-hr rhythm of CYP2E1 expression in the mouse liver.
Hepatology 48: 240-251, 2008.
Shinohara A, Koyanagi S, Hamdan AM, Matsunaga N, Aramaki H, Ohdo S.
Dosing schedule-dependent change in the disruptive effects of interferon-alpha on the circadian clock function.
Life Sci. 83: 574-580, 2008.
Nakagawa H, Koyanagi S, Kuramoto Y, Yoshizumi A, Matsunaga N, Shimeno H, Soeda S, Ohdo S.
Modulation of circadian rhythm of DNA synthesis in tumor cells by inhibiting platelet-derived growth factor signaling.
J. Pharmacol. Sci. 107: 401-407, 2008.
Soeda S, Koyanagi S, Kuramoto Y, Kimura M, Oda M, Kozako T, Hayashida S, Shimeno H.
Anti-apoptotic roles of plasminogen activator inhibitor-1 as a neurotrophic factor in the central nervous system.
Thromb. Haemost. 100: 1014-1020, 2008.
Morikawa A, Hamase K, Miyoshi Y, Koyanagi S, Ohdo S, Zaitsu K.
Circadian changes of D-alanine and related compounds in rats and the effect of restricted feeding on their amounts.
J Chromatogr B Analyt Technol Biomed Life Sci. 87: 168-73, 2008.
Burioka N, Koyanagi S, Endo M, Takata M, Fukuoka Y, Miyata M, Takeda K, Chikumi H, Ohdo S, Shimizu E.
Clock gene dysfunction in patients with obstructive sleep apnoea syndrome.
Eur. Respir. J. 32:105-112, 2008.
Sonoki K, Iwase M, Sasaki N, Ohdo S, Higuchi S, Takata Y, Iida M.
Secretory PLA(2) inhibitor indoxam suppresses LDL modification and associated inflammatory responses in TNFalpha-stimulated human endothelial cells.
Br. J. Pharmacol. 153: 1399-1408, 2008.
Terazono H, Hamdan A, Matsunaga N, Hayasaka N, Kaji H, Egawa T, Makino K, Shigeyoshi Y, Koyanagi S, Ohdo S.
Modulatory effects of 5-fluorouracil on the rhythmic expression of circadian clock genes: A possible mechanism of chemotherapy-induced circadian rhythm disturbances.
Biochem. Pharmacol. 75: 1616-1622, 2008.
Sato F, Bhawal U.K, Kawamoto T, Fujimoto K, Imanaka T, Imaizumi T, Kondo J, Noshiro M, Koyanagi S, Kusumi T, Kato Y, Kijima H.
Basic-helix-loop-helix (bHLH) transcription factor DEC2 binds to HIF-1α and negatively regulates the expression of vascular endothelial growth factor.
Biochem. Pharmacol. 75: 1616-1622, 2008.Genes Cells 13: 131-144, 2008.
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Takiguchi T, Tomita M, Matsunaga N, Nakagawa H, Koyanagi S, Ohdo S.
Molecular basis for rhythmic expression of CYP3A4 in serum-shocked HepG2 cells.
Pharmacogenet. Genomics 17:1047-1056, 2007.
Yamasaki D, Tsujimoto M, Ohdo S, Ohtani H, Sawada Y.
Possible mechanisms for the pharmacokinetic interaction between phenytoin and folinate in rats.
Ther. Drug. Monit. 29: 404-411, 2007.
Tanaka C, Ohtani H, Tsujimoto M, Ohdo S, Taniguchi M, Mizooku Y, Saitoh Y, Kimura M, Uchimaru H, Irie S, Sawada Y.
Effects of dosing interval on the pharmacokinetic interaction between oral small spherical activated charcoal and amlodipine in humans.
J. Clin. Pharmacol. 47: 904-908, 2007.
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Koyanagi S, Okazawa S, Kuramoto Y, Ushijima K, Shimeno H, Soeda S, Okamura H, Ohdo S.
Chronic treatment with prednisolone represses the circadian oscillation of clock gene expression in mouse peripheral tissues.
Mol. Endocrinol. 20: 573-583, 2006.
Koyanagi S, Suyama H, Kuramoto Y, Matsunaga N, Takane H, Soeda S, Shimeno H, Higuchi S, Ohdo S.
Glucocorticoid regulation of 24-hour oscillation in interferon receptor gene expression in mouse liver.
Endocrinology 147: 5037-5040, 2006.
Nakagawa H, Takiguchi T, Nakamura M, Furuyama A, Koyanagi S, Aramaki H, Higuchi S, Ohdo S.
Basis for dosing time-dependent change in the anti-tumor effect of imatinib in mice.
Biochem. Pharmacol. 72: 1237-1245, 2006.
Soeda S, Shinomiya K, Ochiai T, Koyanagi S, Toda A, Eyanagi R, Shimeno H.
Plasminogen activator inhibitor-1 aids nerve growth factor-induced differentiation and survival of pheochromocytoma cells by activating both the extracellular signal-regulated kinase and c-Jun pathways.
Neuroscience 141: 101-108, 2006.
Yoshida M, Kiyofuji H, Koyanagi S, Matsuo A, Fujioka T, To H, Higuchi S, Ohdo S.
Glucocorticoid is involved in food-entrainable rhythm of mu-opioid receptor expression in mouse brainstem and analgesic effect of morphine.
J. Pharmacol. Sci. 101:77-84, 2006.
Kuramoto Y, Hata K, Koyanagi S, Ohdo S, Shimeno H, Soeda S.
Circadian regulation of mouse topoisomerase I gene expression by glucocorticoid hormones.
Biochem. Pharmacol. 71: 1155-1161, 2006.
Hikishima S, Isobe M, Koyanagi S, Soeda S, Shimeno H, Shibuya S, Yokomatsu T.
Synthesis and biological evaluation of 9-(5',5'-difluoro-5'-phosphonopentyl)guanine derivatives for PNP-inhibitors.
Bioorg. Med. Chem. 14: 1660-1670, 2006.
Yamauchi A, Ichimiya T, Inoue K, Taguchi Y, Matsunaga N, Koyanagi S, Fukagawa T, Aramaki H, Higuchi S, Ohdo S.
Cell cycle dependent pharmacology of methotrexate in HL-60
J. Pharmacol. Sci. 99: 335-341, 2006.
Ushijima K, Morikawa T, To H, Higuchi S, Ohdo S.
Chronobiological disturbances with hyperthermia and hypercortisolism induced by chronic mild stress in rats.
Behav. Brain Res. 173: 326-330, 2006
Fuchikami H, Satoh H, Tsujimoto M, Ohdo S, Ohtani H, Sawada Y.
Effects of herbal extracts on the function of human organic anion-transporting polypeptide OATP-B.
Drug. Metab. Dispos. 34: 577-582, 2006.
Kanno M, Araie M, Masuda K, Takase M, Kitazawa Y, Shiose Y, Azuma I, Ogawa N, Ohdo S.
Phase III long-term study and comparative clinical study of nipradilol ophthalmic solution in patients with primary open-angle glaucoma and ocular hypertension. Part 2.
Arzneimittelforschung 56; 820-825, 2006.
Kanno M, Araie M, Masuda K, Takase M, Kitazawa Y, Shiose Y, Azuma I, Ogawa N, Ohdo S.
Phase III long-term study and comparative clinical study of nipradilol ophthalmic solution in patients with primary open-angle glaucoma and ocular hypertension.
Arzneimittelforschung 56: 729-734, 2006.
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Fukuoka Y, Burioka N, Takata M, Ohdo S, Miyata M, Endo M, Shimizu E.
Glucocorticoid administration increases hPer1 mRNA levels in human peripheral blood mononuclear cells in vitro or in vivo.
J. Biol. Rhythms. 20, 550-553, 2005.
Takata M, Burioka N, Ohdo S, Fukuoka Y, Miyata M, Endo M, Suyama H, Shimizu E.
β2-adrenoceptor agonists induced the mammalian clock gene, hPer1, mRNA in cultured human bronchial epithelium cells in vitro.
Chronobiol. Int. 22(4), 777-783, 2005.
Burioka N, Takata M, Okano Y, Ohdo S, Fukuoka Y, Miyata M, Takane H, Endo M, Suyama H, Shimizu E.
Dexamethasone influences human clock gene expression in bronchial epithelium and peripheral blood mononuclear cells in vitro.
Chronobiol. Int. 22(3), 585-590, 2005.
Tabuchi M, To H, Sakaguchi H, Goto N, Takeuchi A, Higuchi S, Ohdo S.
Therapeutic index by combination of adriamycin and docetaxel depends on dosing time in mice.
Cancer Res. 65(18), 8448-8454, 2005.
Takimoto M, Hamada A, Tomoda A, Ohdo S, Ohmura T, Sakato H, Kawatani J, Jodoi T, Nakagawa H, Terazono H, Koyanagi S, Higuchi S, Kimura M, Tukikawa H, Irie S, Saito H, Miike T.
Daily expression of clock genes in whole blood cells in healthy subjects and a patient with circadian rhythm sleep disorder.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 289, 1273-1279, 2005.
Ushijima K, Sakaguchi H, Sato Y, To H, Koyanagi S, Higuchi S, Ohdo S.
Chronopharmacological study of antidepressants in forced swimming test of mice.
J. Pharmacol. Exp. Ther. 315(2), 764-770, 2005.
Yoshida M, Koyanagi S, Matsuo A, Fujioka T, To H, Higuchi S, Ohdo S.
Glucocorticoid hormone regulates the circadian coordination of μ-opioid receptor expression in mouse brainstem.
J. Pharmacol. Exp. Ther. 315, 1119-1124, 2005.
Yamauchi A, Ichimiya T, Inoue K, Taguchi Y, Matsunaga N, Koyanagi S, Fukagawa T, Aramaki H, Higuchi S, Ohdo S.
Cell cycle dependent pharmacology of methotrexate in HL-60.
J. Pharmacol. Sci. 99, 335-341, 2005.
Viyoch J, Matsunaga N, Yoshida M, To H, Higuchi S, Ohdo S.
Effect of haloperidol on mPer1 gene expression in mouse SCN.
J. Biol. Chem. 280 (8) 6309-6315, 2005.
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